XAV939

• Catalog number
  1727-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one
• Description
  A Tankyrase (TNKS) inhibitor (IC₅₀ = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.
• CAS Number
  284028-89-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₄H₁₁F₃N₂OS
• Molecular Weight
  312.31
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (50 mM)
• Handling
  Protect from air and light
• Tag Line
  A Tankyrase (TNKS) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD16879017
• PubChem CID
  2726824
• PubChem CID Link
• SMILES
  C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
• InChi
  InChI=1S/C14H11F3N2OS/c15-14(16, 17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18, 19,20)
• InChi Key
  KLGQSVMIPOVQAX-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  XAV939  
• Short name
  XAV939
• Alternative name
  XAV939

Similar products