Xanthohumol

• Catalog number
  2258-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)- 2-propen-1-one
• Description
  Cell-permeable. A bioactive flavonoid antioxidant found in the flowering hops plant. Binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II). Impairs prostate cancer cell growth and proliferation.
• CAS Number
  6754-58-1
• Structure Available
  Yes
• Peptide sequence
  No
• Salt Form
  No
• Molecular Formula
  C₂₁H₂₂O₅
• Molecular Weight
  354.4
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (~35 mg/ml) or EtOH (~35 mg/ml)
• Handling
  Protect from light and mositure
• Tag Line
  Valosin-containing protein (VCP) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD00210576
• PubChem CID
  639665
• PubChem CID Link
• SMILES
  CC(=CCC1=C(C=C(C(=C1O)C(=O)C=CC2=CC=C(C=C2)O)OC)O)C
• InChi
  InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+
• InChi Key
  ORXQGKIUCDPEAJ-YRNVUSSQSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Xanthohumol  
• Short name
  Xanthohumol
• Alternative name
  Xanthohumol

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