WZ4002

• Catalog number
  2461-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide
• Description
  A third generation EGFR inhibitor. Selectively inhibits mutant EGFR T790M. Inhibits EGFR phosphorylation and induces siginificant tumor regressionin murine model of EGFR T790M. WZ4002 can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more effectively than Src inhibitors.
• CAS Number
  1213269-23-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₅H₂₇ClN₆O₃
• Molecular Weight
  494.97
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  An EGFR T790M inhibitor.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  44607530
• PubChem CID Link
• SMILES
  CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC
• InChi
  InChI=1S/C25H27ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30)
• InChi Key
  ITTRLTNMFYIYPA-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  WZ4002  
• Short name
  WZ4002
• Alternative name
  WZ4002

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