Vinorelbine Tartrate

  • Catalog number
    1957-5
  • Price
    140.48 USD
  • Size
    5 mg
  • Alternative_name
    3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate
  • Description
    A semi-synthetic vinca alkaloid that displays potent anti-mitotic and anti-tumor properties. Its main mechanism of action is thought to be inhibition of microtubule dynamics, which results in mitotic arrest and eventual cell death. Acts as a microtubule destabilizing agent. At high concentrations, it stimulates microtubule depolymerization and mitotic spindle destruction. At lower clinically relevant concentrations, vinorelbine blocks mitotic progression. Its main targets are tubulin and microtubules. Unlike the taxanes, which bind poorly to soluble tubulin, vinorelbine can bind both soluble and microtubule-associated tubulin.
  • CAS Number
    125317-39-7
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₄₅H₅₄N₄O₈.C₈H₁₂O₁₂
  • Molecular Weight
    1079.11
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    Water (~ 10 mg/ml)
  • Handling
    Protect from light and moisture
  • Tag Line
    An anti-mitotic and antitumor agent
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    48 months
  • MDL Number
    MFCD03613607
  • PubChem CID
    607791
  • SMILES
    CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9) (C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C (=O)O)O)(C(=O)O)O
  • InChi
    InChI=1S/C45H54N4O8.2C4H6O6/c1-8-27-19-28-22-44(40(51)55-6, 36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32) 54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2, 37(43)49)39(57-26(3)50)45(38, 53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9, 16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t28?,37-,38+,39+,42+,43+, 44-,45-;2*1-,2-/m011/s1
  • InChi Key
    CILBMBUYJCWATM-NPJYPKOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    Vinorelbine Tartrate
  • Alternative name
    Vinorelbine Tartrate
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