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Alternative_name
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; ZD6474, Zactima
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Description
A potent inhibitor of kinase insert domain-containing receptor [KDR/vascular endothelial growth factor receptor (VEGFR) 2] tyrosine kinase activity (IC₅₀ = 40 nM). This compound also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC₅₀ = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC₅₀ = 500 nM) but shows selectivity relating to a range of other tyrosine and serine-threonine kinases.
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CAS Number
443913-73-3
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₂H₂₄BrFN₄O₂
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Molecular Weight
475.35
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (30 mg/ml) or EtOH (10 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
A potent VEGFR kinase inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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MDL Number
MFCD07772346
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PubChem CID
3081361
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SMILES
CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC
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InChi
InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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InChi Key
UHTHHESEBZOYNR-UHFFFAOYSA-N
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MSDS Available
Yes