Urokinase Inhibitor Screening Kit (Fluorometric)

• Catalog number
  K727-100
• Price
  Please ask
• Size
  100 assays

• Description
  Simple Assay to Screen Urokinase Inhibitors
• Summary
  • Detection Method – Fluorescence (Ex/Em = 350/450 nm) • Application: - Screening potential inhibitors of Urokinase - Characterize/study urokinase inhibitors
• Features Benefits
  • Rapid & simple • Reliable test for screening potential inhibitors of Urokinase • Includes Urokinase-specific Inhibitor [GGACK Dihydrochloride]
• Storage Conditions
  -20°C
• Shipping Conditions
  gel pack
• Shelf life
  12 months
• Background
  Urokinase (Urokinase-type plasminogen activator, uPA, EC 3.4.21.73) is a serine protease, which catalyzes the conversion of the plasminogen to active plasmin, which in turn participates in thrombolysis. Urokinase inhibitors have potential applications in cancer therapy. Biovision’s Urokinase Inhibitor Screening Kit utilizes the ability of Urokinase to cleave a synthetic AMC-based peptide substrate to release AMC, which can be detected by measuring its fluorescence at Ex/Em = 350/450 nm. In the presence of the Urokinase specific inhibitors, the enzyme activity is inhibited or completely abolished. This assay kit is a simple, sensitive, and rapid tool to screen potential Urokinase inhibitors.
• Data Sheet Link
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Urokinase   Inhibitor   Screening   Kit   Fluorometric  
• Short name
  Urokinase Inhibitor Screening Kit (Fluorometric)
• Alternative name
  Urokinase suppressor detection reagent (fluorescence)
• Alternative technique
  kits
• Alternative to gene target
  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832

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