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Alternative_name
Chidamide; Epidaza; N-(2-amino-4-fluorophenyl)-4-[[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]methyl]benzamide; (E)-N-(2-amino-4-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide; N-(2-Amino-4-fluorophenyl)-4-(((1-oxo-3-(3-pyridinyl)-2-propen-1-yl)amino)methyl)benzamide; CS-055; HBI-8000
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Description
Tucidinostat is an inhibitor of histone deacetylases (HDACs) with IC₅₀ values of 95 nM, 160 nM, 67 nM and 78 nM for HDAC1, HDAC2, HDAC3 and HDAC10 respectively. It shows potent antitumor activity. It inhibits several human derived tumor cell lines, such as HL-60, U2OS, LNCaP with GI₅₀ values of 0.4-40 μM but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells. It (12.5-50 mg/kg, p.o) reduces tumor growth in mouse xenograft models.
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CAS Number
1616493-44-7
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Structure Available
1
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Molecular Formula
C₂₂H₁₉FN₄O₂
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Molecular Weight
390.41
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Cell Permeable
1
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Purity
≥98%
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Solubilities
~20 mg/ml in DMSO and DMF
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
An inhibitor of histone deacetylases
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Storage Condition
-20ºC
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Shipping Condition
RT
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Shelf Life
36 months
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MDL Number
MFCD28100259
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PubChem CID
12136798
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SMILES
C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=C(C=C3)F)N
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InChi
InChI=1S/C22H19FN4O2/c23-18-8-9-20(19(24)12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)/b10-5+
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InChi Key
SZMJVTADHFNAIS-BJMVGYQFSA-N
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MSDS Available
1
