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Alternative_name
O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1-6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1-4)]-2-deoxy-D-streptamine
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Description
Tobramycin is an aminoglycoside antibiotic that binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding. Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections.
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CAS Number
32986-56-4
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Structure Available
Yes
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Molecular Formula
C₁₈H₃₇N₅O₉
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Molecular Weight
467.52
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Cell Permeable
Yes
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Purity
≥94%(Titration)
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Solubilities
H₂O (>45 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
An aminoglycoside antibiotic
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Storage Condition
-20°C
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Shipping Condition
Gel Pack
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Shelf Life
36 months
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MDL Number
MFCD00077885
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PubChem CID
36294
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SMILES
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(CC(C(O3)CN)O)N)N
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InChi
InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1
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InChi Key
NLVFBUXFDBBNBW-PBSUHMDJSA-N
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MSDS Available
Yes
