Thiostrepton

• Catalog number
  9677-250
• Price
  Please ask
• Size
  250 mg

• Alternative_name
  Alaninamide, Bryamycin, Thiactin
• Description
  Thiostrepton is a large cyclic antibiotic commonly used in topical antibiotic ointments. It inhibits bacterial protein synthesis. It blocks translation by interfering with elongation factors (EF) involved in ribosomal GTPase activity. Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
• CAS Number
  1393-48-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₇₂H₈₅N₁₉O₁₈S₅
• Molecular Weight
  1664.89
• Cell Permeable
  Yes
• Purity
  Assay: ≥900 u/mg
• Solubilities
  DMSO (~5 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  An antibiotic and protein synthesis inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00135828
• PubChem CID
  16129666
• PubChem CID Link
• SMILES
  CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
• InChi
  InChI=1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,
• InChi Key
  NSFFHOGKXHRQEW-DVRIZHICSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Thiostrepton  
• Short name
  Thiostrepton
• Alternative name
  Thiostrepton

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