TACE Antibody

• Catalog number
  3222-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  TACE/ADAM17
• Target Alternative Name
  TACE, CD156b, Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat
• Immunogen Sequence
  KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TACE
• Accession
  P78536
• Gene Id
  6868
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin.
• Purification
  Affinity purified
• Application
  Western blot
• Application And Usages
  Western blotting (1-2 µg/ml). However, the optimal conditions should be determined individually. The immunoaffinity purified antibody detects 80-130 kDa bands, which may represent mature protein, precursor and glycosylated TACE. HeLa and Jurkat cell lysate can be used as positive control.
• Description
  Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-α is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-α. TNF-α converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bond metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGF-α, L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TACE  
• Gene symbol
  ADAM17
• Short name
  TACE Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  TACE (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:195
• Gene
  ADAM17
• Long gene name
  ADAM metallopeptidase domain 17
• Synonyms gene
  • TACE
• Synonyms gene name
  • tumor necrosis factor, alpha, converting enzyme
• Synonyms
  • cSVP
  • CD156B
• Synonyms name
  • cartilage snake venom-like protease
  • TNF-alpha convertase enzyme
  • a disintegrin and metalloproteinase 17
• GenBank acession
  • U69611
• Locus
  2p25.1
• Discovery year
  1997-04-10
• Entrez gene record
  6868
• Pubmed identfication
  • 9034190
  • 9574564
• Classification
  • ADAM metallopeptidase domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000090425
• Locus Specific Databases
  • LRG_1203

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products