StemRegenin 1, Free base

• Catalog number
  2642-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol; SR1
• Description
  A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines, StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.
• CAS Number
  1227633-49-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₂₃N₅OS
• Molecular Weight
  429.54
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A promoter of self-renewal of hematopoietic stem cells (HSCs)
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  48 months
• PubChem CID
  46199207
• PubChem CID Link
• SMILES
  CC(C)N1C=NC2=C1N=C(N=C2NCCC3=CC=C(C=C3)O)C4=CSC5=CC=CC=C54
• InChi
  InChI=1S/C24H23N5OS/c1-15(2)29-14-26-21-23(25-12-11-16-7-9-17(30)10-8-16)27-22(28-24(21)29)19-13-31-20-6-4-3-5-18(19)20/h3-10,13-15,30H,11-12H2,1-2H3,(H,25,27,28)
• InChi Key
  BGFHMYJZJZLMHW-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  StemRegenin   Free   base  
• Short name
  StemRegenin 1, Free base
• Alternative name
  StemRegenin 1, Free base

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