Sitravatinib

#

• Catalog number
  B2539-25
• Price:

  420.66 USD

  Ask for price
• Size
  25 mg

# #

• Alternative_name
  MGCD516; MGCD-516; N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; MG516
• Description
  Sitravatinib (MGCD516; MG516) is a potent receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT , FLT3, DDR2, DDR1, TRKA, TRKB, respectively.
• CAS Number
  1123837-84-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₃H₂₉F₂N₅O₄S
• Molecular Weight
  629.68
• Cell Permeable
  True
• Purity
  ≥98%
• Solubilities
  >30 mg/ml in DMSO
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A potent receptor tyrosine kinase (RTK) inhibitor
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  25212148
• PubChem CID Link
• SMILES
  COCCNCC1=CN=C(C=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
• InChi
  InChI=1S/C33H29F2N5O4S/c1-43-15-14-36-18-20-2-8-25(38-19-20)29-17-26-30(45-29)28(10-13-37-26)44-27-9-7-23(16-24(27)35)40-32(42)33(11-12-33)31(41)39-22-5-3-21(34)4-6-22/h2-10,13,16-17,19,36H,11-12,14-15,18H2,1H3,(H,39,41)(H,40,42)
• InChi Key
  WLAVZAAODLTUSW-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  True

#

• Gene target
  Sitravatinib  
• Short name
  Sitravatinib
• Alternative name
  Sitravatinib

Similar products