Sirtuin 6, human recombinant

• Catalog number
  7578-10
• Price
  Please ask
• Size
  10 ug

• Synonyms
  SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6
• Alternative_names
  SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6
• Description
  A NAD-dependent protein deacetylase
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥90%
• Assay
  SDS-PAGE
• Molecular Weight
  ~45.0 kDa. Human sirtuin 6 (aa 1-355) is fused at the N-terminus to a His-tag.
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  6 months
• Appearance
  Liquid
• Physical form description
  0.2 um-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.
• Background Information
  Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Sirtuin  
• Gene symbol
  SIRT6
• Short name
  Sirtuin 6, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Sirtuin 6, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:14934
• Gene
  SIRT6
• Long gene name
  sirtuin 6
• Synonyms gene name
  • sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6
  • sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
• GenBank acession
  • AF233396
• Locus
  19p13.3
• Discovery year
  2001-03-20
• Entrez gene record
  51548
• Pubmed identfication
  • 10873683
• Classification
  • Sirtuins
• VEGA ID
  OTTHUMG00000181847

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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