Sinomenine hydrochloride

Alternative_name

Cucoline; (9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one, monohydrochloride; NSC 76021
Description

Sinomenine is a natural plant alkaloid that displays anti-inflammatory properties. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain. Sinomenine potentiates renewal of human embryonic stem cells.
CAS Number

6080-33-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₉H₂₃NO₄ • HCl
Molecular Weight

365.85
Cell Permeable

1
Purity

≥98%
Solubilities

~20 mg/ml Water
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

An anti-inflammatory agent
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
MDL Number

MFCD01714307
PubChem CID

5464452
PubChem CID Link
SMILES

CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC.Cl
InChi

InChI=1S/C19H23NO4.ClH/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19;/h4-5,9,12-13,22H,6-8,10H2,1-3H3;1H/t12-,13+,19-;/m1./s1
InChi Key

YMEVIMJAUHZFMW-VUIDNZEBSA-N
Data Sheet Link
MSDS Available

1