SC-514

• Catalog number
  2442-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  5-(Thien-3-yl)-3-aminothiophene-2-carboxamide
• Description
  A reversible, competitive inhibitor of IKK2 (IC₅₀ = 11.2 µM). Does not inhibit other IKK isoforms, or other kinases. Displays dose-dependent inhibition of the transcription of NK-κB dependent genes in cell culture.
• CAS Number
  354812-17-2
• Structure Available
  Yes
• Peptide sequence
  No
• Salt Form
  No
• Molecular Formula
  C₉H₈N₂OS₂
• Molecular Weight
  224.3
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (~25 mg/ml)
• Handling
  Protect from light and air
• Tag Line
  A reversible, competitive inhibitor of IKK2
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD00206459
• PubChem CID
  2807869
• PubChem CID Link
• SMILES
  C1=CSC=C1C2=CC(=C(S2)C(=O)N)N
• InChi
  InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12)
• InChi Key
  BMUACLADCKCNKZ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SC-514  
• Gene symbol
  ERMAP, SRSF2, MIR514A1, MIR514A2, MIR514A3
• Short name
  SC-514
• Alternative name
  SC-514

Gene info

• Identity
  HGNC:15743
• Gene
  ERMAP
• Long gene name
  erythroblast membrane associated protein (Scianna blood group)
• Synonyms gene
  • RD
  • SC
• Synonyms gene name
  • Radin blood group
  • Scianna blood group
  • erythroblast membrane-associated protein
  • erythroblast membrane-associated protein (RD and SC blood groups)
  • erythroblast membrane-associated protein (Scianna blood group)
• Synonyms
  • BTN5
• GenBank acession
  • AF311284
• Locus
  1p34.2
• Discovery year
  2001-09-06
• Entrez gene record
  114625
• Pubmed identfication
  • 11549310
• RefSeq identity
  • NM_018538
• Classification
  • V-set domain containing
  • Butyrophilins
  • Blood group antigens
• VEGA ID
  OTTHUMG00000007619
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • LRG_806

Gene info

• Identity
  HGNC:10783
• Gene
  SRSF2
• Long gene name
  serine and arginine rich splicing factor 2
• Synonyms gene
  • SFRS2
• Synonyms gene name
  • splicing factor, arginine/serine-rich 2
  • serine/arginine-rich splicing factor 2
• Synonyms
  • SC-35
  • SC35
  • PR264
  • SFRS2A
• Synonyms name
  • SR splicing factor 2
• GenBank acession
  • M90104
• Locus
  17q25.2
• Discovery year
  1993-09-17
• Entrez gene record
  6427
• Pubmed identfication
  • 8530103
  • 20516191
• RefSeq identity
  • NM_003016
• Classification
  • Serine and arginine rich splicing factors
  • RNA binding motif containing
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000177547
• Locus Specific Databases
  • LRG_640

Gene info

• Identity
  HGNC:32148
• Gene
  MIR514A1
• Long gene name
  microRNA 514a-1
• Synonyms gene
  • MIRN514-1
  • MIR514-1
• Synonyms gene name
  • microRNA 514-1
• Synonyms
  • hsa-mir-514-1
• Locus
  Xq27.3
• Discovery year
  2005-07-15
• Entrez gene record
  574516
• RefSeq identity
  • NR_030238
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:32149
• Gene
  MIR514A2
• Long gene name
  microRNA 514a-2
• Synonyms gene
  • MIRN514-2
  • MIR514-2
• Synonyms gene name
  • microRNA 514-2
• Synonyms
  • hsa-mir-514-2
• Locus
  Xq27.3
• Discovery year
  2005-07-15
• Entrez gene record
  574517
• RefSeq identity
  • NR_030239
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:32150
• Gene
  MIR514A3
• Long gene name
  microRNA 514a-3
• Synonyms gene
  • MIRN514-3
  • MIR514-3
• Synonyms gene name
  • microRNA 514-3
• Synonyms
  • hsa-mir-514-3
• Locus
  Xq27.3
• Discovery year
  2005-07-15
• Entrez gene record
  574518
• RefSeq identity
  • NR_030240
• Classification
  • MicroRNA MIR506 family

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