SB 216763

• Catalog number
  1769-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
• Description
  A potent, cell-permeable and ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC₅₀ > 10 μM). Stimulates glycogen synthesis, gene transcription and is neuroprotective.
• CAS Number
  280744-09-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₁₂Cl₂N₂O₂
• Molecular Weight
  371.22
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (50 mM)
• Handling
  Protect from air and light
• Tag Line
  A GSK-3 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD09753369
• PubChem CID
  176158
• PubChem CID Link
• SMILES
  CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl
• InChi
  InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
• InChi Key
  JCSGFHVFHSKIJH-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  216763  
• Short name
  SB 216763
• Alternative name
  SB 216763

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