(S)-Duloxetine hydrochloride

Alternative_name

(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride,Duloxetine HCl,Cymbalta
Description

(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg, respectively). It is used to treat stress urinary incontinence, psychiatric and metabolic disorders. It is also used for treating diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal and low back pain (LBP).
CAS Number

136434-34-9
Structure Available

1
Molecular Formula

C18H19NOS • HCl
Molecular Weight

333.88
Cell Permeable

1
Purity

≥97% by HPLC
Solubilities

~ 25 mg/ml DMSO
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A serotonin and norepinephrine reuptake inhibitor
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
MDL Number

MFCD06407958
PubChem CID

60834
PubChem CID Link
SMILES

CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl
InChi

InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
InChi Key

BFFSMCNJSOPUAY-LMOVPXPDSA-N
Data Sheet Link
MSDS Available

1

Name

Cloning, Molecular
Concept

Scope note: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Tree numbers
- E05.393.220
Qualifiers

drug effects, methods, radiation effects