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Alternative_name
(S)-3-(1-(Dimethylamino)ethyl)phenyl ethyl(methyl)carbamate (2R,3R)-2,3-dihydroxysuccinate; Carbamic acid, ethylmethyl-, 3-((1S)-1-(dimethylamino)ethyl)phenyl ester, (2R,3R)-2,3-dihydroxybutanedioate (1:1); SDZ-ENA 713; ENA 713; Exelon
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Description
Rivastigmine is a cholinesterase (ChE) inhibitor that inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) with IC₅₀ values of 0.037 μM and 4.15 μM respectively. It is used for the treatment of dementia in Alzheimer's disease and Parkinson's disease.
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CAS Number
129101-54-8
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Structure Available
1
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Salt Form
1
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Molecular Formula
C₁₈H₂₈N₂O₈
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Molecular Weight
400.42
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Cell Permeable
True
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Purity
≥ 95%
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Solubilities
~16 mg/ml in DMSO and ethanol, ~10 mg/ml in PBS, pH 7.2, ~25 mg/ml in DMF
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
An inhibitor of butyrylcholinesterase and acetylcholinesterase
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Storage Condition
-20ºC
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Shipping Condition
RT
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Shelf Life
36 months
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MDL Number
MFCD03700731
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PubChem CID
6918078
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SMILES
CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C.C(C(C(=O)O)O)(C(=O)O)O
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InChi
InChI=1S/C14H22N2O2.C4H6O6/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4;5-1(3(7)8)2(6)4(9)10/h7-11H,6H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-;1-,2-/m01/s1
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InChi Key
GWHQHAUAXRMMOT-MBANBULQSA-N
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MSDS Available
1
