RITA

Alternative_name

5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol; NSC 652287
Description

RITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 and induces its accumulation in tumor cells. RITA prevents p53-HDM2 interaction in vitro and in vivo and affects p53 interaction with several negative regulators. It induces expression of p53 target genes and apoptosis in various tumor cell lines expressing wild-type p53.
CAS Number

213261-59-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₄H₁₂O₃S₂
Molecular Weight

292.37
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>25 mg/ml) or EtOH (>5 mg/ml)
Handling

Protect from air and light
Tag Line

A p53 activator
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
MDL Number

MFCD03235294
PubChem CID

374536
PubChem CID Link
SMILES

C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO
InChi

InChI=1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2
InChi Key

KZENBFUSKMWCJF-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes