Rilpivirine hydrochloride

Alternative_name

TMC-278, (E)-4-((4-((4-(2-cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile hydrochloride, TMC278
Description

Rilpivirine hydrochloride is a diarylpyrimidine derivative that acts as a reverse transcriptase inhibitor with antiviral activity against HIV-1. Rilpivirine is associated with a low rate of transient serum aminotransferase elevations during therapy and has been implicated in rare cases of clinically apparent acute liver injury.
CAS Number

700361-47-3
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₁₉ClN₆
Cell Permeable

True
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI)
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

11711114
PubChem CID Link
SMILES

CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)C=CC#N.Cl
InChi

InChI=1S/C22H18N6.ClH/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19;/h3-9,11-13H,1-2H3,(H2,25,26,27,28);1H/b4-3+;
InChi Key

KZVVGZKAVZUACK-BJILWQEISA-N
Data Sheet Link
MSDS Available

True