Resminostat (hydrochloride)

Alternative_name

3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide, monohydrochloride; 4SC-201 hydrochloride; RAS2410 hydrochloride; (E)-3-[1-(4-dimethylaminomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-N-hydroxy-acrylamide hydrochloride
Description

Resminostat is a potent inhibitor of histone deacetylases (HDAC) 1, 3 and 6 with IC₅₀ ranging from 43–72 nM. It induces hyperacetylation of histone H4, abrogates cell growth and induces apoptosis in multiple myeloma cells with an IC₅₀ of 2.5-3 µM. It inhibits cell proliferation, induces G0/G1 cell cycle arrest, decreases levels of cyclin D1, cdc25a, Cdk4 and pRb and upregulates p21.
CAS Number

1187075-34-8
Structure Available

True
Salt Form

True
Molecular Formula

C₁₆H₂₀ClN₃O₄S
Molecular Weight

385.87
Cell Permeable

True
Purity

>98% (HPLC)
Solubilities

~0.5 mg/ml in PBS, pH 7.2 in 0, ~10 mg/ml in in DMSO, ~0.5 mg/ml in DMF in 0
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

An inhibitor of HDAC
Storage Condition

-20ºC
Shipping Condition

RT
Shelf Life

36 months
PubChem CID

16662815
PubChem CID Link
SMILES

CN(C)CC1=CC=C(C=C1)S(=O)(=O)N2C=CC(=C2)C=CC(=O)NO.Cl
InChi

InChI=1S/C16H19N3O4S.ClH/c1-18(2)11-13-3-6-15(7-4-13)24(22,23)19-10-9-14(12-19)5-8-16(20)17-21;/h3-10,12,21H,11H2,1-2H3,(H,17,20);1H/b8-5+;
InChi Key

BVXPKDRKHXARHY-HAAWTFQLSA-N
Data Sheet Link
MSDS Available

True