RepSox
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Catalog number1894-5
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PricePlease ask
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Size5 mg
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Alternative_name2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine; E-616452
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DescriptionCell-permeable. A TGF-β type I receptor (ALK5) inhibitor. Inhibits ALK5 autophosphorylation (IC₅₀ = 4 nM). Can replace one of the four reprogramming factors Sox-2. RepSox has been successfully used in the direct reprogramming of mouse fibroblasts through induction of Nanog transcription.
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CAS Number446859-33-2
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₇H₁₃N₅
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Molecular Weight287.32
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>20 mg/ml)
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HandlingProtect from air and light
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Tag LineA TGF-β type I receptor (ALK5) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD09037561
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PubChem CID449054
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SMILESCC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4
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InChiInChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15 (21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
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InChi KeyLBPKYPYHDKKRFS-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameRepSox
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Alternative nameRepSox
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