Regorafenib

• Catalog number
  2891-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY 73-4506
• Description
  Regorafenib is a multi-kinase inhibitor targeting angiogenic (VEGFR, TIE-2), stromal (PDGFR-β) and oncogenic (RAF, RET and c-KIT) receptor tyrosine kinases, with IC₅₀s of 17, 40 and 69 nM for c-KIT, VEGFR2, B-Raf, respectively. Displays potential antiangiogenic and antineoplastic activities.
• CAS Number
  755037-03-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₁₅ClF₄N₄O₃
• Molecular Weight
  482.81
• Cell Permeable
  yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A multi-kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  11167602
• PubChem CID Link
• SMILES
  CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
• InChi
  InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
• InChi Key
  FNHKPVJBJVTLMP-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Regorafenib  
• Short name
  Regorafenib
• Alternative name
  Regorafenib

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