Refametinib

• Catalog number
  B1889-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide; BAY 86-9766
• Description
  Refametinib (BAY 86-9766; previously RDEA119) is a highly selective and potent orally available inhibitor of MEK 1 and MEK 2.  It displays potent in vitro and in vivo antitumor activity in multiple preclinical cancer models, including melanoma, colorectal cancer, non-small cell lung cancer, epidermal carcinoma, and HCC.
• CAS Number
  923032-37-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₂₀F₃IN₂O₅S
• Molecular Weight
  572.34
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A highly selective and potent orally available inhibitor of MEK 1 and MEK 2.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  44182295
• PubChem CID Link
• SMILES
  COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F
• InChi
  InChI=1S/C19H20F3IN2O5S/c1-30-15-7-13(21)16(22)18(24-14-3-2-10(23)6-12(14)20)17(15)25-31(28,29)19(4-5-19)8-11(27)9-26/h2-3,6-7,11,24-27H,4-5,8-9H2,1H3/t11-/m0/s1
• InChi Key
  RDSACQWTXKSHJT-NSHDSACASA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Refametinib  
• Short name
  Refametinib
• Alternative name
  Refametinib

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