Recombinant Murine Interleukin-27/p28 (IL-30)
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Catalog number4187-1000
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PricePlease ask
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Size1 mg
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SynonymsInterleukin-30, IL-30, IL-27/p28, p28, Interleukin-27, Interleukin-27/p28, IL-27, Interleukin-27 subunit α, IL-27 subunit α, IL27-A, Il27, Il27a, IL-27p28.
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Alternative_namesInterleukin-30, IL-30, IL-27/p28, p28, Interleukin-27, Interleukin-27/p28, IL-27, Interleukin-27 subunit α, IL-27 subunit α, IL27-A, Il27, Il27a, IL-27p28.
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DescriptionA regulator of B- and T-lymphocyte's activities
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RecombinantYes
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SourceE. coli
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Purity by SDS PAGE≥97%
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AssaySDS-PAGE
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Purity≥97%
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Biological activityMeasured by dose-dependent inhibition of TGF-β & Il-6-induced IL-17A expression in mouse CD4 splenocytes. 50 ng/ml of mouse p28 is capable of inhibiting >25% of Il-17A expression in this assay.
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Results50 ng/ml
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Molecular Weight23.7 kDa
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Storage Temp-20°C
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ShippingGel pack
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Shelf Life12 months
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AppearanceLyophilized protein
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Physical form descriptionLyophilized from 10 mM NaP, pH 7.5
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Reconstitution InstructionsReconstitute in H₂O to a concentration of 0.1-0.5 mg/ml. The solution can then be diluted into other aqueous buffers
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Background InformationThe p28 subunit of IL-27 (IL-27/p28), also known as Interleukin-30 (IL-30), is a member of the IL-12 family of cytokines. When combined with EBI3 (Epstein-Barr virus induced gene 3), p28 forms a heterodimer known as IL-27. p28 is thought to be a pro-inflammatory cytokine inducing immuno-modulatory effects, but the details of these effects are currently unclear and research is focused on delineating its specific biological functions. Recombinant mouse p28 is a non-glycosylated protein, containing 207 amino acids, with a molecular weight of 23.7 kDa.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolIL27, SNORD114-30, SNORD116-30, SNORD115-30, IGKV2-30, RNU6-30P, IGHV3-30, IGLV3-30, IGHVII-30-21, IGHVII-30-1
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Short nameRecombinant Murine Interleukin-27/p28 (IL-30)
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Alternative nameRec. Murine Interleukin-27/p28 (Interleukin-30)
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nameinterleukin 27
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Synonyms gene
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Synonyms gene name
- interleukin 30
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-11-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 114-30
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Synonyms
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Locus
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Discovery year2006-09-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 116-30
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Synonyms
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Locus
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Discovery year2011-08-22
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Entrez gene record
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 115-30
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 2-30
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin kappa locus at 2p11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRNA, U6 small nuclear 30, pseudogene
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Synonyms gene
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Synonyms gene name
- RNA, U6 small nuclear 30
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Locus
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Discovery year2008-06-10
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Entrez gene record
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RefSeq identity
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 3-30
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin lambda variable 3-30 (pseudogene)
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Synonyms gene name
- immunoglobulin lambda variable 3-30
- immunoglobulin lambda variable 3-30 pseudogene
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GenBank acession
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Locus
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Discovery year2000-05-08
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin lambda locus at 22q11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable (II)-30-21 (pseudogene)
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Synonyms
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Locus
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Discovery year2016-11-10
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable (II)-30-1 (pseudogene)
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Synonyms gene name
- immunoglobulin heavy variable (II)-30-1
- immunoglobulin heavy variable (II)-30-1 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-17
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Methods or procedures used to obtain samples of URINE.
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Tree numbers
- E01.370.225.998.762
- E05.200.998.762
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Qualifiersethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data