Recombinant Coronavirus Spike Protein (SARS-CoV S, His tag)

• Catalog number
  P1520-10
• Price
  Please ask
• Size
  10 µg

• Synonyms
  Spike glycoprotein, S glycoprotein, E2, Peplomer protein
• Alternative_names
  Spike glycoprotein, S glycoprotein, E2, Peplomer protein
• Description
  Glycoprotein that enables viral entry into the host cell
• Recombinant
  True
• Source
  E. coli
• Purity by SDS PAGE
  >90%
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Sterile Filtered colorless solution
• Physical form description
  Liquid
• Background Information
  SARS-CoV is an enveloped, single and positive-stranded RNA virus. Cell entry of severe acute respiratory syndrome coronavirus (SARS-CoV) is mediated by the viral spike (S) protein. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. For viral entry, the surface unit (S1) of SARS S binds to the cellular receptor angiotensin converting enzyme 2 (ACE2) and the transmembrane unit (S2) then fuses the viral membrane with a host cell membrane. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. Because the S protein of SARS-CoV is involved in receptor recognition, as well as virus attachment and entry, it represents one of the most important targets for the development of SARS vaccines and therapeutics.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Conjugation
  histidine
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Coronavirus   Spike   Protein   SARS-CoV   His   tag  
• Gene symbol
  SARS1, SARS2
• Short name
  Recombinant Coronavirus Spike Protein (SARS-CoV S, His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Alternative name
  Rec. Coronavirus Spike Protein (SARS-CoV S, histidine detection labelled)
• Alternative technique
  rec
• Virus
  coronavirus

Gene info

• Identity
  HGNC:10537
• Gene
  SARS1
• Long gene name
  seryl-tRNA synthetase 1
• Synonyms gene
  • SARS
• Synonyms gene name
  • seryl-tRNA synthetase
• Synonyms
  • SERS
• Synonyms name
  • serine tRNA ligase 1, cytoplasmic
• GenBank acession
  • BC009390
• Locus
  1p13.3
• Discovery year
  1995-06-09
• Entrez gene record
  6301
• Pubmed identfication
  • 9431993
• RefSeq identity
  • NM_006513
• Classification
  • Aminoacyl tRNA synthetases, Class II
• VEGA ID
  OTTHUMG00000011726

Gene info

• Identity
  HGNC:17697
• Gene
  SARS2
• Long gene name
  seryl-tRNA synthetase 2, mitochondrial
• Synonyms gene
  • SARSM
• Synonyms gene name
  • serine-tRNA ligase, mitochondrial
  • seryl-tRNA synthetase 2
• Synonyms
  • FLJ20450
  • mtSerRS
  • SerRSmt
  • SARS
  • SERS
  • SYS
• Synonyms name
  • serine tRNA ligase 2, mitochondrial
• GenBank acession
  • AB029948
• Locus
  19q13.2
• Discovery year
  2002-10-09
• Entrez gene record
  54938
• Pubmed identfication
  • 10764807
• RefSeq identity
  • NM_017827
• Classification
  • Aminoacyl tRNA synthetases, Class II
• VEGA ID
  OTTHUMG00000182691

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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