recMAb™ Anti-PMS2 Antibody
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Catalog number
A2223-100
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Price
Please ask
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Size
100 µg
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Antibody Target
PMS2
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Target Alternative Name
MLH4, PMSL2, HNPCC4, PMS2CL, H_DJ0042M02.9
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Antibody Type
Monoclonal
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Clone
PMS2/4373R
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Species Reactivities
Human
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Immunogen Sequence
Synthetic peptide targeting residues within aa 1-100 of PMS2
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Accession
P54278
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Gene Id
5395
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Appearance
Colorless liquid
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Form
Liquid
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Concentration
1 mg/ml
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Formulation
In 10 mM PBS
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Purification
Protein A/G purified
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Application
Immunohistochemistry (IHC)
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Application And Usages
IHC (1-2 µg/ml)
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Description
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.
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Storage Condition
-20ºC
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Shipping Condition
Gel Pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
PMS2
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Short name
recMAb™ Anti-PMS2 Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Isotype
IgG
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Alternative name
recMAb™ Antibody toPMS2 (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
PMS2 postmeiotic segregation increased 2 (S. cerevisiae), HNPCC4 and PMS2CL and PMSL2, PMS2 and IDBG-7921 and ENSG00000122512 and 5395, MutSalpha complex binding, nuclei, Pms2 and IDBG-259679 and ENSMUSG00000079109 and 18861, PMS2 and IDBG-640975 and ENSBTAG00000007364 and 527039
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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