PS48
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Catalog number1869-25
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PricePlease ask
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Size25 mg
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Alternative_name(2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acid
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DescriptionAn allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site. It has recently been found that a combination of PS48, sodium butyrate (Cat. No. 1609-1000), a histone deacetylase inhibitor and the gene Oct-4, could enhance the reprogramming efficiency of keratinocytes isolated from human skin or hair follicles over 25-fold.
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CAS Number1180676-32-7
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₇H₁₅ClO₂
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Molecular Weight286.75
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Cell PermeableYes
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Purity≥95% by HPLC
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SolubilitiesDMSO (100 mM) or EtOH (50 mM)
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HandlingProtect from air and light
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Tag LineAn allosteric PDK1 activator
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD17215962
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PubChem CID44141940
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SMILESC1=CC=C(C=C1)C(=CC(=O)O)CCC2=CC=C(C=C2)Cl
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InChiInChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
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InChi KeyLLJYFDRQFPQGNY-QINSGFPZSA-N
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MSDS AvailableYes
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Gene target
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Short namePS48
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Alternative namePS48
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