Poziotinib

• Catalog number
  9519-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one; HM781-36B; NOV120101
• Description
  Poziotinib is an irreversible Pan-HER inhibitor with IC₅₀s of 3 nM, 5 nM and 23 nM for HER1, HER2, and HER4 respectively. Displays antineoplastic activity.
• CAS Number
  1092364-38-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₁Cl₂FN₄O₃
• Molecular Weight
  491.34
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>5 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A an irreversible Pan-HER inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  25127713
• PubChem CID Link
• SMILES
  COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C
• InChi
  InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)
• InChi Key
  LPFWVDIFUFFKJU-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Poziotinib  
• Short name
  Poziotinib
• Alternative name
  Poziotinib

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