PIK-93

Alternative_name

PIK-93; PIK 93; PIK93; N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide
Description

PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.
CAS Number

593960-11-3
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₄H₁₆ClN₃O₄S₂
Molecular Weight

389.88
Cell Permeable

Yes
Purity

>98%
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

PI3Kγ/PI4KIIIβ/PI3Kα inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD12922510
PubChem CID

6852167
PubChem CID Link
SMILES

CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO
InChi

InChI=1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)
InChi Key

JFVNFXCESCXMBC-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:2901
Gene

DLG2
Long gene name

discs large MAGUK scaffold protein 2
Synonyms gene name
- discs, large homolog 2, chapsyn-110 (Drosophila)
- discs, large homolog 2 (Drosophila)
- discs large homolog 2
Synonyms
- PSD-93
- PSD93
- chapsyn-110
- PPP1R58
Synonyms name
- protein phosphatase 1, regulatory subunit 58
GenBank acession
- U32376
Locus

11q14.1
Discovery year

1997-04-21
Entrez gene record

1740
Pubmed identfication
- 8755482
- 9806853
RefSeq identity
- NM_001364
Classification
- Protein phosphatase 1 regulatory subunits
- Membrane associated guanylate kinases
- PDZ domain containing
VEGA ID

OTTHUMG00000134309