Phospho SMAD2 (Ser465) Antibody
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Catalog number
A1950-100
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Price
Please ask
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Size
100 µl
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Antibody Target
Phospho SMAD2 (Ser465)
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Target Alternative Name
MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2
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Antibody Type
Polyclonal
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Species Reactivities
Zebrafish, Bovine, Sheep, Rabbit, Porcine, Rat, Chicken, Monkey, Mouse, Human
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Immunogen Sequence
KLH-conjugated synthetic peptide targeting a sequence within the C-term region of human SMAD2
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Accession
Q15796
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Gene Id
4087
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Appearance
Liquid
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Form
Liquid
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Formulation
In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
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Purification
Affinity purified
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Application
Immunohistochemistry (IHC), Western Blotting
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Application And Usages
WB 1:500 - 1:1000, IHC 1:100 - 1:200
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Description
Smads are a group of intracellular proteins that act as signal transducers for the members of TGF-beta superfamily. Based on their roles, Smads are categorized in three groups: receptor regulated (R-Smads) which include Smad 1,2,3,5 and 8; co-regulatory Smads, which includes only Smad4 and inhibitory Smads (I-Smads), which includes Smad6 and 7. When TGF-beta superfamily serine/threonine kinase receptors are activated, this leads to phosphorylation of R-Smads, which then forms a heteromeric complex with co-Smad (Smad4) and as a result, this complex translocates to the nucleus and regulate gene expression of several downstream targets in association with other proteins. I-Smads, on the other hand, do not allow the R-Smads to form a heteromeric complex with co-Smads, thus disrupting the TGF-beta signaling pathway.
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Storage Condition
-20ºC
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Shipping Condition
Gel Pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Western Blot Verified
True
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Immunocytochemistry Verified
True
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Immunofluorescence Verified
False
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Immunoprecipitation Verified
False
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FACS Verified
False
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ELISA Verified
False
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ChIP Verified
False
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Dot Blot Verified
False
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Flow Cytometry Verified
False
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
SMAD2
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Short name
Phospho SMAD2 (Ser465) Antibody
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
IgG
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Alternative name
phosphorilated SMAD family member 2 (Ser465) (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
SMAD family member 2, hMAD-2 and hSMAD2 and JV18 and JV18-1 and MADH2 and MADR2, SMAD2 and IDBG-3127 and ENSG00000175387 and 4087, transforming growth factor beta receptor, nuclei, Smad2 and IDBG-159056 and ENSMUSG00000024563 and 17126, SMAD2 and IDBG-644642 and ENSBTAG00000039916 and 515125,516010
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Gene info
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Identity
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Gene
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Long gene name
SMAD family member 2
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Synonyms gene
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Synonyms gene name
- MAD, mothers against decapentaplegic homolog 2 (Drosophila)
- SMAD, mothers against DPP homolog 2 (Drosophila)
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Synonyms
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GenBank acession
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Locus
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Discovery year
1996-11-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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