Phospho PTEN (Ser370) Antibody
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Catalog number
A1952-100
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Price
Please ask
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Size
100 µl
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Antibody Target
Phospho PTEN (Ser370)
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Target Alternative Name
MMAC1; TEP1; Phosphatidylinositol 3;4;5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog
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Antibody Type
Polyclonal
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Species Reactivities
Bovine, Porcine, Dog, Monkey, Zebrafish, Mouse, Human
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Immunogen Sequence
KLH-conjugated synthetic peptide targeting a sequence within the C-term region of human PTEN
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Accession
P60484
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Gene Id
5728
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Appearance
Colorless liquid
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Form
Liquid
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Formulation
In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
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Purification
Affinity purified
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Application
Immunohistochemistry (IHC), Western Blotting
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Application And Usages
IHC 1:100 - 1:200, WB 1:500 - 1:1000
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Description
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
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Storage Condition
-20ºC
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Shipping Condition
Gel Pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Western Blot Verified
True
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Immunocytochemistry Verified
True
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Immunofluorescence Verified
False
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Immunoprecipitation Verified
False
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FACS Verified
False
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ELISA Verified
False
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ChIP Verified
False
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Dot Blot Verified
False
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Flow Cytometry Verified
False
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
PTEN, PTENP1
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Short name
Phospho PTEN (Ser370) Antibody
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
IgG
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Alternative name
phosphorilated phosphatase and tensin homolog (Ser370) (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
phosphatase and tensin homolog, 10q23del and BZS and CWS1 and DEC and GLM2 and MHAM and MMAC1 and PTEN1 and TEP1, PTEN and IDBG-81409 and ENSG00000171862 and 5728, phosphatidylinositol-3, nuclei, Pten and IDBG-158878 and ENSMUSG00000013663 and 19211, PTEN and IDBG-637256 and ENSBTAG00000009498 and 540786
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Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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