Phleomycin

• Catalog number
  2724-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (2R,​3S,​4S,​5R,​6R)-​2-​(((2R,​3S,​4S,​5S,​6S)-​2-​(2-​(6-​amino-​2-​(3-​amino-​1-​((2,​3-​diamino-​3-​oxopropyl)amino)-​3-​oxopropyl)-​5-​methylpyrimidine-​4-​carboxamido)-​3-​((5-​((1-​((2-​(4-​((4-​guanidinobutyl)carbamoyl)-​4',​5'-​dihydro-​[2,​4'-​bithiazol]-​2'-​yl)ethyl)amino)-​3-​hydroxy-​1-​oxobutan-​2-​yl)amino)-​3-​hydroxy-​4-​methyl-​5-​oxopentan-​2-​yl)amino)-​1-​(1H-​imidazol-​4-​yl)-​3-​oxopropoxy)-​4,​5-​dihydroxy-​6-​(hydroxymethyl)tetrahydro-​2H-​pyran-​3-​yl)oxy)-​3,​5-​dihydroxy-​6-​(hydroxymethyl)tetrahydro-​2H-​pyran-​4-​yl carbamate,​ copper(II) salt,​ monohydrochloride
• Description
  Phleomycin is an antibiotic produced by Streptomyces verticullus and is structurally related to Bleomycin. Used as a selective agent in transformation experiments with mammalian cells, plant cells and yeast. Its cytotoxic action results from its ability to cause fragmentation of DNA. In Vitro studies indicate that Phleomycin causes accumulation of cells in the G2 phase of the cell cycle.
• CAS Number
  11006-33-0
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₅₅H₈₅N₂₀O₂₁S₂Cu • HCl
• Molecular Weight
  1526.5
• Cell Permeable
  Yes
• Purity
  ³95%
• Solubilities
  H₂O (~ 20 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  An antibiotic and selective agent
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00131846
• SMILES
  NC(O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@H](OC(C3=CNC=N3)C(NC(C4=NC(C(NCC(N)C(N)=O)CC(N)=O)=NC(N)=C4C)=O)C(NC(C(O)C(C)C(NC(C(O)C)C(NCCC5=NC(C6=NC(C(NCCCCNC(N)=N)=O)=CS6)CS5)=O)=O)C)=O)O[C@@H](CO)[C@@H](O)[C@@H]2O)O[C@H](CO)[C@H]1[O-])=O.[H]Cl.[Cu+2]
• InChi
  InChI=1S/C55H85N20O21S2.ClH.Cu/c1-19-32(72-45(75-43(19)58)24(11-30(57)79)67-12-23(56)44(59)85)49(89)74-34(40(25-13-63-18-68-25)94-53-42(38(83)36(81)28(14-76)93-53)95-52-39(84)41(96-55(62)91)37(82)29(15-77)92-52)50(90)69-21(3)35(80)20(2)46(86)73-33(22(4)78)48(88)65-10-7-31-70-27(17-97-31)51-71-26(16-98-51)47(87)64-8-5-6-9-66-54(60)61;;/h13,16,18,20-24,27-29,33-42,52-53,67,76-78,80-81,83-84H,5-12,14-15,17,56H2,1-4H3,(H2,57,79)(H2,59,85)(H2,62,91)(H,63,68)(H,64,87)(H,65,88)(H,69,90)(H,73,86)(H,74,89)(H2,58,72,75)(H4,60,61,66);1H;/q-1;;+2/t20?,21?,22?,23?,24?,27?,28-,29+,33?,34?,35?,36+,37+,38-,39-,40?,41+,42-,52+,53-;;/m0../s1
• InChi Key
  XDWMLXOKMKKZFQ-LTUREVHFSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Phleomycin  
• Short name
  Phleomycin
• Alternative name
  Phleomycin

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