PF299804

• Catalog number
  2678-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (E)-N-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide; PF299; Dacomitinib
• Description
  PF299804 (Dacomitinib) is a potent, irreversible pan-HER inhibitor with IC₅₀’s of 6, 46, and 74 nM for ErbB1(HER1), ErbB2 (HER2), and ErbB4 (HER4), respectively. PF299804 inhibits ErbB1 autophosphorylation in A431 cells with an IC₅₀ of 15 nM.
• CAS Number
  1110813-31-4
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₄H₂₅ClFN₅O₂
• Molecular Weight
  469.94
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>15 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent pan-HER inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  11511120
• PubChem CID Link
• SMILES
  COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)C=CCN4CCCCC4
• InChi
  InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+
• InChi Key
  LVXJQMNHJWSHET-AATRIKPKSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  PF299804  
• Short name
  PF299804
• Alternative name
  PF299804

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