Panobinostat (LBH589)

  • Catalog number
    1612-25
  • Price
    1163.93 USD
  • Size
    25 mg
  • Alternative_name
    LBH589, LBN-589, NVP-LBH590
  • Description
    Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC₅₀ values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12 nM, respectively. And to A2780 proliferation, IC₅₀ value is 4.6±1.8 nM.
  • CAS Number
    404950-80-7
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₁H₂₃N₃O₂
  • Molecular Weight
    349.43
  • Cell Permeable
    Yes
  • Purity
    ≥99% by HPLC
  • Solubilities
    DMSO
  • Handling
    Protect from air and moisture
  • Tag Line
    A HDAC inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    RT
  • Shelf Life
    24months
  • MDL Number
    MFCD09833242
  • PubChem CID
    6918837
  • SMILES
    CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO
  • InChi
    InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6- 16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24, 25)/b11-10+
  • InChi Key
    FPOHNWQLNRZRFC-ZHACJKMWSA-N
  • MSDS Available
    Yes
  • Gene target
  • Short name
    Panobinostat (LBH589)
  • Alternative name
    Panobinostat (LBH589)
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