Osteoprotegerin (OPG), human recombinant

• Catalog number
  4312-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Osteoprotegerin, OPG
• Alternative_names
  Osteoprotegerin, OPG, Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, TNFRSF11B, OCIF
• Description
  A decoy receptor for RANKL
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥98%
• Assay
  SDS-PAGE
• Purity
  ≥98%
• Biological activity
  Determined by its ability to neutralize the stimulation of U937 cells treated with 10 ng/ml of sRANKL.
• Results
  10 ng/ml
• Molecular Weight
  20.0 kDa
• Storage Temp
  -20°C
• Shipping
  Gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Sterile filtered and then lyophilized
• Reconstitution Instructions
  Reconstitute in 5 mM Tris, pH 7.5 to a concentration of 0.1-1.0 mg/ml. The solution can be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
• Background Information
  Human OPG (Osteoprotegerin), also known as OCIF (Osteoclastogenesis inhibitory factor), is a member of the TNF receptor superfamily. Recombinant human OPG/OCIF specifically acts on bone tissues and increases bone mineral density and bone volume associated with a decrease of active osteoclast number. Recombinant human OPG is a 20 kDa protein, comprising of 174 amino acid residues.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Osteoprotegerin   OPG  
• Gene symbol
  TNFRSF11B, BTF3P11
• Short name
  Osteoprotegerin (OPG), recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Osteoprotegerin (OPG), H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:11909
• Gene
  TNFRSF11B
• Long gene name
  TNF receptor superfamily member 11b
• Synonyms gene
  • OPG
• Synonyms gene name
  • osteoprotegerin
  • tumor necrosis factor receptor superfamily, member 11b
• Synonyms
  • OCIF
  • TR1
• Synonyms name
  • osteoclastogenesis inhibitory factor
• GenBank acession
  • U94332
• Locus
  8q24.12
• Discovery year
  1997-09-05
• Entrez gene record
  4982
• Pubmed identfication
  • 9108485
• Classification
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000164969

Gene info

• Identity
  HGNC:1126
• Gene
  BTF3P11
• Long gene name
  basic transcription factor 3 pseudogene 11
• Synonyms gene
  • BTF3L1
• Synonyms gene name
  • basic transcription factor 3, like 1
  • basic transcription factor 3-like 1, pseudogene
  • basic transcription factor 3, like 1 pseudogene
• Synonyms
  • HUMBTFB
  • TNFRSF11B
  • OPG
  • OCIF
• Synonyms name
  • lambda h27A
  • BTF3 homologue
• GenBank acession
  • M90354
• Locus
  13q22.3
• Discovery year
  1997-12-12
• Entrez gene record
  690
• Pubmed identfication
  • 9325059
  • 1386332
• RefSeq identity
  • NR_026983
• VEGA ID
  OTTHUMG00000017097

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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