Okadaic acid

Alternative_name

OA
Description

A Potent inhibitor of protein phosphatases 1 and 2A in numerous cell types. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Non-phorbol type tumor promoter. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells, but inhibits glucocorticoid-induced apoptosis in T-cell hybridomas.
CAS Number

78111-17-8
Structure Available

Yes
Salt Form

No
Molecular Formula

C₄₄H₆₈O₁₃
Molecular Weight

805
Cell Permeable

Yes
Purity

>98%
Solubilities

DMSO (>1 mg/ml) and EtOH (>1 mg/ml)
Handling

Protect from moisture. Tumor promoter
Tag Line

A protein phosphatsae inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

12 months
MDL Number

MFCD00083455
PubChem CID

446512
PubChem CID Link
SMILES

CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O
InChi

InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1
InChi Key

QNDVLZJODHBUFM-WFXQOWMNSA-N
Data Sheet Link
MSDS Available

Yes