MS37452

Alternative_name

1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone; 1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine; 1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone; 1-{4-[(2,3-dimethoxyphenyl)carbonyl]piperazin-1-yl}-2-(3-methylphenoxy)ethanone
Description

MS37452 is a competitive inhibitor of CBX7 (Chromobox homolog 7) chromodomain binding to trimethylated lysine 27 of histone 3 (H3K27me3). It inhibits CBX7-H3K27me3 binding with a Ki of 43.0 μM. At 250 µM, it derepresses transcription of Polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in PC3 prostate cancer cells.
CAS Number

423748-02-1
Structure Available

True
Salt Form

false
Molecular Formula

C₂₂H₂₆N₂O₅
Molecular Weight

398.45
Cell Permeable

True
Purity

≥98%
Solubilities

~30 mg/ml in ethanol, DMSO and DMF in 0
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

An inhibitor of CBX7 chromodomain binding to H3K27me3
Storage Condition

-20ºC
Shipping Condition

RT
Shelf Life

36 months
PubChem CID

1072048
PubChem CID Link
SMILES

CC1=CC(=CC=C1)OCC(=O)N2CCN(CC2)C(=O)C3=C(C(=CC=C3)OC)OC
InChi

InChI=1S/C22H26N2O5/c1-16-6-4-7-17(14-16)29-15-20(25)23-10-12-24(13-11-23)22(26)18-8-5-9-19(27-2)21(18)28-3/h4-9,14H,10-13,15H2,1-3H3
InChi Key

LUMCNRKHZRYQOV-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

True