MLN-4924

Alternative_name

((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentylmethyl sulfamate
Description

A potent and selective inhibitor of NEDD8 (Neural precursor cell expressed, developmentally down-regulated 8)-activating enzyme (NAE) (IC₅₀ = 4.7 nM) with potential anticancer activity. NAE activates NEDD8, an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP). Supresses the growth of tumor xenografts in mice.
CAS Number

905579-51-3
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₁H₂₅N₅O₄S
Molecular Weight

443.53
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~10 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective NEDD8 inhibitor
Storage Condition

-20°C
Shipping Condition

Gel pack
Shelf Life

24 months
PubChem CID

16720766
PubChem CID Link
SMILES

C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=O)N
InChi

InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1
InChi Key

MPUQHZXIXSTTDU-QXGSTGNESA-N
Data Sheet Link
MSDS Available

Yes