ML-365

Alternative_name

2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide
Description

ML-365 is a potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC₅₀ values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated potassium channels, KCNQ2 and KV11.1 (hERG).
CAS Number

947914-18-3
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₂₀N₂O₃
Molecular Weight

360.41
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>30 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

46785920
PubChem CID Link
SMILES

CC1=CC=CC(=C1)C(=O)NC2=CC(=CC=C2)NC(=O)C3=CC=CC=C3OC
InChi

InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
InChi Key

UTAJHKSGYJSZBR-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes