ML-210
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Catalog numberB2710-5
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PricePlease ask
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Size5 mg
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Alternative_name[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-methanone,DPI10
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DescriptionML-210 is a selective and covalent inhibitor of glutathione peroxidase 4 (GPX4). ML-210 binds the GPX4 selenocysteine residue. It reduces viability of mesenchymal-state KP4 cells, an effect that can be blocked by the lipoxygenase inhibitor PD 146176 (Cat. No. B2313). ML-210 displays anti-cancer activity.
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CAS Number1360705-96-9
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₂H₂₀Cl₂N₄O₄
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Molecular Weight475.32
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Cell Permeable1
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Purity≥98%
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Solubilities>20 mg/ml DMSO
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HandlingDo not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag LineA glutathione peroxidase 4 (GPX4) inhibitor
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Storage Condition-20ºC
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Shipping ConditionGel Pack
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Shelf Life36 months
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PubChem CID49766530
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SMILESCC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)[N+](=O)[O-]
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InChiInChI=1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3
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InChi KeyVIBHJPDPEVVDTB-UHFFFAOYSA-N
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MSDS Available1
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Gene target
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Gene symbolRN7SKP210, MIR210, RNA5SP210
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Short name-210
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Alternative namemilliliter-210
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Gene info
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Identity
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Gene
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Long gene nameRN7SK pseudogene 210
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Synonyms gene name
- RNA, 7SK small nuclear pseudogene 210
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Locus
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Discovery year2013-03-19
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Entrez gene record
Gene info
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Identity
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Gene
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Long gene namemicroRNA 210
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Synonyms gene
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Synonyms
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Locus
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Discovery year2004-04-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNAs
Gene info
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Identity
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Gene
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Long gene nameRNA, 5S ribosomal pseudogene 210
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Synonyms gene
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Synonyms gene name
- RNA, 5S ribosomal 210
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Locus
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Discovery year2011-11-16
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Entrez gene record