ML-210

Alternative_name

[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-methanone,DPI10
Description

ML-210 is a selective and covalent inhibitor of glutathione peroxidase 4 (GPX4). ML-210 binds the GPX4 selenocysteine residue. It reduces viability of mesenchymal-state KP4 cells, an effect that can be blocked by the lipoxygenase inhibitor PD 146176 (Cat. No. B2313). ML-210 displays anti-cancer activity.
CAS Number

1360705-96-9
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₂₀Cl₂N₄O₄
Molecular Weight

475.32
Cell Permeable

1
Purity

≥98%
Solubilities

>20 mg/ml DMSO
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A glutathione peroxidase 4 (GPX4) inhibitor
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

49766530
PubChem CID Link
SMILES

CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)[N+](=O)[O-]
InChi

InChI=1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3
InChi Key

VIBHJPDPEVVDTB-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

1