Mithramycin A

• Catalog number
  B1532-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  A 2371, Antibiotic LA 7017, Aureolic Acid, NSC 24559, PA 144, Plicamycin
• Description
  Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or transcription factors and, thereby, chromatin accessibility to transcriptional machinery. As a selective Sp1 inhibitor, mithramycin A binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, which inhibits their expression. Mithramycin A (at 10-200 nM) can sensitize tumor cells to TRAIL-induced apoptosis and has been used to selectively target tumor cells in many different cancer models.
• CAS Number
  18378-89-7
• Structure Available
  Yes
• Molecular Formula
  C₅₂H₇₆O₂₄
• Molecular Weight
  1085.15
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO (>20 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A DNA-binding, anti-tumor and neuroprotective antibiotic used as a chemotherapeutic agent.
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD00135618
• PubChem CID
  163659
• PubChem CID Link
• SMILES
  CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O
• InChi
  InChI=1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27+,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43-,44-,45+,49+,50+,51-,52+/m1/s1
• InChi Key
  CFCUWKMKBJTWLW-BKHRDMLASA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Mithramycin  
• Short name
  Mithramycin A
• Alternative name
  Mithramycin A

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