MERS-CoV Spike S2 Protein
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Catalog number
P1624-10
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Price
Please ask
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Size
10 ug
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Synonyms
Middle East respiratory syndrome coronavirus; Human betacoronavirus 2c EMC/2012; Middle East respiratory syndrome-related coronavirus; S glycoprotein; EMC/2012; E2; Peplomer protein; Spike protein S2
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Alternative_names
Middle East respiratory syndrome coronavirus; Human betacoronavirus 2c EMC/2012; Middle East respiratory syndrome-related coronavirus; S glycoprotein; EMC/2012; E2; Peplomer protein; Spike protein S2
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Description
S2 protein enables membrane fusion
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Recombinant
1
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Source
Baculovirus
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Purity by SDS PAGE
≥ 85% by SDS-PAGE
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Endotoxin Level
< 1 EU/ug of protein as determined by LAL method
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Molecular Weight
60.7 kDa
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Storage Temp
-20°C
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Shipping
Gel Pack
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Shelf Life
12 months
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Concentration
0.25 mg/ml (determined by Absorbance at 280nm)
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Appearance
Liquid
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Background Information
MERS-CoV is a coronavirus which causes the Middles East Respiratory Syndrome (MERS). MERS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The spike protein is responsible for allowing the virus to attach and fuse with the membrane of a host cell. Spike glycoprotein is cleaved into three chains: S1, S2’ and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for membrane fusion. MERS-CoV S mediates viral attachment and fusion to human cells via human cellular receptor DPP4, also known as CD26. The S protein plays an important role in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
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Amino acid sequence
The target protein is expressed with the sequence (aa 752-1296) of MERS-CoV spike protein S2 fused to His-tag at the C-terminus.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Product images
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