LY-2784544

Alternative_name

Gandotinib
Description

LY2784544 is a potent, selective and ATP-competitive JAK2 inhibitor (IC₅₀ = 3 nM). effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. LY2784544 effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC₅₀= 20 and 55 nM, respectively). In comparison, LY2784544 is much less potent at inhibiting interleukin-3-stimulated wild-type JAK2-mediated signaling and cell proliferation (IC₅₀ = 1183 and 1309 nM, respectively).
CAS Number

1229236-86-5
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₃H₂₅ClFN₇O
Molecular Weight

469.94
Cell Permeable

Yes
Purity

≥98%
Solubilities

DMSO (>50 mg/ml)
Handling

Protect from air and light
Tag Line

A potent, selective and ATP-competitive JAK2 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

46213929
PubChem CID Link
SMILES

CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F
InChi

InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4,9,11-12H,5-8,10,13H2,1-2H3,(H2,27,28,29,30)
InChi Key

SQSZANZGUXWJEA-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes