LXR-623

• Catalog number
  B2454-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  WAY-252623; 2-(2-chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole; WAY252623; LXR623
• Description
  LXR-623 is a potent and selective LXR (liver X receptor) agonist. Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.
• CAS Number
  875787-07-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₁₂ClF₅N₂
• Molecular Weight
  422.78
• Cell Permeable
  True
• Purity
  ≥98% by HPLC
• Solubilities
  >40 mg/ml in DMSO
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A selective LXR modulator
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  16734800
• PubChem CID Link
• SMILES
  C1=CC2=C(N(N=C2C(=C1)C(F)(F)F)CC3=C(C=C(C=C3)F)Cl)C4=CC=C(C=C4)F
• InChi
  InChI=1S/C21H12ClF5N2/c22-18-10-15(24)9-6-13(18)11-29-20(12-4-7-14(23)8-5-12)16-2-1-3-17(19(16)28-29)21(25,26)27/h1-10H,11H2
• InChi Key
  KYWWJENKIMRJBI-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  True

• Gene target
  LXR-623  
• Gene symbol
  MIR623, NR1H3, NR1H2
• Short name
  LXR-623
• Alternative name
  LXR-623

Gene info

• Identity
  HGNC:32879
• Gene
  MIR623
• Long gene name
  microRNA 623
• Synonyms gene
  • MIRN623
• Synonyms
  • hsa-mir-623
• Locus
  13q32.3
• Discovery year
  2006-05-17
• Entrez gene record
  693208
• RefSeq identity
  • NR_030353
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:7966
• Gene
  NR1H3
• Long gene name
  nuclear receptor subfamily 1 group H member 3
• Synonyms gene name
  • nuclear receptor subfamily 1, group H, member 3
• Synonyms
  • LXR-a
  • RLD-1
  • LXRa
• Synonyms name
  • liver X receptor-alpha
• GenBank acession
  • U22662
• Locus
  11p11.2
• Discovery year
  1999-09-17
• Entrez gene record
  10062
• Pubmed identfication
  • 8621574
  • 7744246
• Classification
  • Nuclear receptor subfamily 1 group H
• VEGA ID
  OTTHUMG00000150628

Gene info

• Identity
  HGNC:7965
• Gene
  NR1H2
• Long gene name
  nuclear receptor subfamily 1 group H member 2
• Synonyms gene
  • UNR
• Synonyms gene name
  • ubiquitously-expressed nuclear receptor
  • nuclear receptor subfamily 1, group H, member 2
• Synonyms
  • NER
  • NER-I
  • RIP15
  • LXR-b
  • LXRb
• Synonyms name
  • liver X receptor-beta
• GenBank acession
  • U14534
• Locus
  19q13.3
• Discovery year
  1994-09-19
• Entrez gene record
  7376
• Pubmed identfication
  • 7782080
  • 7971966
• Classification
  • Nuclear receptor subfamily 1 group H
• VEGA ID
  OTTHUMG00000183036

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