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Alternative_name
4-[(3aS,4R,9bR)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid
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Description
LIN28 is an RNA-binding protein that regulates the maturation of the let-7 microRNAs through its two distinct cold shock and zinc-knuckle domains. LIN28 inhibitor LI71 binds the cold shock domain of LIN28 and suppresses the activity of LIN28 against let-7 in leukemia cells and embryonic stem cells. LI71 shows an IC₅₀ of ~7 μM in the fluorescence polarization assay using LIN28 and pre-elements of members of the let-7 family.
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CAS Number
1357248-83-9
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Structure Available
1
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Molecular Formula
C₂₁H₂₁NO₃
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Molecular Weight
335.4
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Cell Permeable
1
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Purity
≥97%
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Solubilities
Soluble in methanol
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
An inhibitor of LIN28
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Storage Condition
-20ºC
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Shipping Condition
RT
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Shelf Life
36 months
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MDL Number
MFCD07363437
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PubChem CID
6541811
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SMILES
CCOC1=CC=CC2=C1NC(C3C2C=CC3)C4=CC=C(C=C4)C(=O)O
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InChi
InChI=1S/C21H21NO3/c1-2-25-18-8-4-7-17-15-5-3-6-16(15)19(22-20(17)18)13-9-11-14(12-10-13)21(23)24/h3-5,7-12,15-16,19,22H,2,6H2,1H3,(H,23,24)/t15-,16+,19+/m1/s1
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InChi Key
QWJMABCFVYELBB-GJYPPUQNSA-N
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MSDS Available
1
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
