Lenvatinib

• Catalog number
  B1157-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide; E7080
• Description
  Lenvatinib is a potent inhibitor of multiple receptor tyrosine kinases, with IC₅₀ values of  22 nM, 4 nM, 5.2 nM, 39 nM and 35 nM on VEGFR-1, VEGFR-2, VEGFR-3, PDGFRβ and RET, respectively. It inhibits SCF- and VEGF-induced angiogenesis of human umbilical vein endothelial cells that express the SCF receptor KIT, with IC₅₀ values of 5.2 nM and 5.1 nM, respectively. Lenvatinib inhibits tumor growth in the human small cell lung cancer H146 xenograft model.
• CAS Number
  417716-92-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₁₉ClN₄O₄
• Molecular Weight
  426.85
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>35 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent inhibitor of multiple receptor tyrosine kinases
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  9823820
• PubChem CID Link
• SMILES
  COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl
• InChi
  InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
• InChi Key
  WOSKHXYHFSIKNG-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Lenvatinib  
• Short name
  Lenvatinib
• Alternative name
  Lenvatinib

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