KC7F2
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Catalog number9641-10
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PricePlease ask
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Size10 mg
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Alternative_nameN,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide
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DescriptionKC7F2 is a small molecule HIF-1 pathway inhibitor that inhibits HIF-1α protein translation, but not transcription. It inhibits hypoxia-induced expression of several HIF target genes, such as carbonic anhydrase IX, matrix metalloproteinase 2, enolase 1, and endothelin 1. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC₅₀ value of 15-25 µM.
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CAS Number927822-86-4
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₆H₁₆Cl₄N₂O₄S₄
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Molecular Weight570.38
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>50 mg/ml)
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HandlingProtect from air and light
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Tag LineA small molecule HIF-1 pathway inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID16047442
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SMILESC1=CC(=C(C=C1Cl)S(=O)(=O)NCCSSCCNS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl)Cl
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InChiInChI=1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2
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InChi KeyREQLACDIZMLXIC-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameKC7F2
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Alternative nameKC7F2
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