K-604, ACAT-1 Inhibitor

• Catalog number
  B2926-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-(4-(2-(1H-benzo[d]imidazol-2-ylthio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide; 4-[2-(1H-Benzimidazol-2-ylthio)ethyl]-N-[6-methyl-2,4-bis(methylthio)-3-pyridinyl]-1-piperazineacetamide
• Description
  K-604 is an inhibitor of acyl-CoA:cholesterol acyltransferase 1 (ACAT1). The IC₅₀ values of K-604 for human ACAT-1 and ACAT-2 are 0.45 μM and 102.85 μM respectively, showing that K-604 is 229-fold more selective for ACAT-1. It suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels. It stimulates collagen production in cultured smooth muscle cells and modulates plaque phenotype in apolipoprotein E-knockout mice.
• CAS Number
  561023-90-3
• Structure Available
  True
• Salt Form
  false
• Molecular Formula
  C₂₃H₃₀N₆OS₃
• Molecular Weight
  502.72
• Cell Permeable
  True
• Purity
  95%
• Solubilities
  Soluble in DMSO in 0
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  An inhibitor of ACAT1
• Storage Condition
  -20ºC
• Shipping Condition
  RT
• Shelf Life
  36 months
• PubChem CID
  9892288
• PubChem CID Link
• SMILES
  CC1=CC(=C(C(=N1)SC)NC(=O)CN2CCN(CC2)CCSC3=NC4=CC=CC=C4N3)SC
• InChi
  InChI=1S/C23H30N6OS3/c1-16-14-19(31-2)21(22(24-16)32-3)27-20(30)15-29-10-8-28(9-11-29)12-13-33-23-25-17-6-4-5-7-18(17)26-23/h4-7,14H,8-13,15H2,1-3H3,(H,25,26)(H,27,30)
• InChi Key
  VGGMTOYKEDKFLN-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  True
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  K-604   ACAT-1   Inhibitor  
• Gene symbol
  ACAT1, SOAT1, TUBA1B, ERVK3-1, H4C13, MIR604, RAP2A, GPC4
• Short name
  K-604, ACAT-1 Inhibitor
• Alternative name
  K-604, ACAT-1 suppressor

Gene info

• Identity
  HGNC:93
• Gene
  ACAT1
• Long gene name
  acetyl-CoA acetyltransferase 1
• Synonyms gene
  • ACAT
• Synonyms gene name
  • acetyl-Coenzyme A acetyltransferase 1
• Synonyms
  • THIL
• Synonyms name
  • acetoacetyl Coenzyme A thiolase
• GenBank acession
  • D90228
• Locus
  11q22.3
• Discovery year
  1991-08-12
• Entrez gene record
  38
• Pubmed identfication
  • 1979337
• RefSeq identity
  • NM_000019
• VEGA ID
  OTTHUMG00000166381
• Locus Specific Databases
  • LRG_1400

Gene info

• Identity
  HGNC:11177
• Gene
  SOAT1
• Long gene name
  sterol O-acyltransferase 1
• Synonyms gene
  • SOAT
  • STAT
• Synonyms gene name
  • sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
• Synonyms
  • ACAT
  • ACAT1
• Synonyms name
  • acyl-Coenzyme A: cholesterol acyltransferase
• GenBank acession
  • L21934
• Locus
  1q25.2
• Discovery year
  1998-11-04
• Entrez gene record
  6646
• Pubmed identfication
  • 8407899
• RefSeq identity
  • NM_003101
• VEGA ID
  OTTHUMG00000035253

Gene info

• Identity
  HGNC:18809
• Gene
  TUBA1B
• Long gene name
  tubulin alpha 1b
• Synonyms
  • K-ALPHA-1
• Synonyms name
  • tubulin, alpha, ubiquitous
• GenBank acession
  • AF081484
• Locus
  12q13.12
• Discovery year
  2007-02-12
• Entrez gene record
  10376
• Pubmed identfication
  • 12054644
  • 6646120
• RefSeq identity
  • NM_006082
• Classification
  • Tubulins
• VEGA ID
  OTTHUMG00000170410

Gene info

• Identity
  HGNC:30466
• Gene
  ERVK3-1
• Long gene name
  endogenous retrovirus group K3 member 1
• Synonyms gene name
  • endogenous retrovirus group K3, member 1
• Synonyms
  • HERV-K(HML6-1)
• GenBank acession
  • AK054868
  • BC010118
  • BC011670
• Locus
  19q13.43
• Discovery year
  2011-05-05
• Entrez gene record
  105372481
• Pubmed identfication
  • 15533715
  • 21542922
• VEGA ID
  OTTHUMG00000150367

Gene info

• Identity
  HGNC:4791
• Gene
  H4C13
• Long gene name
  H4 clustered histone 13
• Synonyms gene
  • H4FK
  • HIST1H4L
• Synonyms gene name
  • H4 histone family, member K
  • histone 1, H4l
  • histone cluster 1, H4l
  • histone cluster 1 H4 family member l
• Synonyms
  • H4.k
  • H4/k
• GenBank acession
  • X83548
• Locus
  6p22.1
• Discovery year
  1998-09-07
• Entrez gene record
  8368
• Pubmed identfication
  • 9031620
  • 9439656
  • 12408966
• RefSeq identity
  • NM_003546
• Classification
  • H4 histones
• VEGA ID
  OTTHUMG00000016211

Gene info

• Identity
  HGNC:32860
• Gene
  MIR604
• Long gene name
  microRNA 604
• Synonyms gene
  • MIRN604
• Synonyms
  • hsa-mir-604
• Locus
  10p11.23
• Discovery year
  2006-05-16
• Entrez gene record
  693189
• RefSeq identity
  • NR_030335
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:9861
• Gene
  RAP2A
• Long gene name
  RAP2A, member of RAS oncogene family
• Synonyms gene
  • RAP2
• Synonyms
  • K-REV
• GenBank acession
  • AF205602
• Locus
  13q32.1
• Discovery year
  1989-06-30
• Entrez gene record
  5911
• Classification
  • RAS type GTPase family
• VEGA ID
  OTTHUMG00000017240

Gene info

• Identity
  HGNC:4452
• Gene
  GPC4
• Long gene name
  glypican 4
• Synonyms
  • K-glypican
• Synonyms name
  • glypican proteoglycan 4
• GenBank acession
  • AF030186
• Locus
  Xq26.2
• Discovery year
  1996-08-08
• Entrez gene record
  2239
• Pubmed identfication
  • 9787072
• RefSeq identity
  • NM_001448
• Classification
  • Glypicans
• VEGA ID
  OTTHUMG00000022434
• Locus Specific Databases
  • Global Variome shared LOVD

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